Leinco Technologies

Anti-Human DEDD2

Product Code:
 
LEI-D315
Product Group:
 
Primary Antibodies
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
Ambient
Storage:
 
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
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CodeSizePrice
LEI-D315-20ug20 ug£199.00
Quantity:
LEI-D315-0.1mg0.1 mg£591.00
Quantity:
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This product comes from: US.
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Further Information

Concentration:
0.5 mg/ml
Conjugate/Tag/Label:
Purified No Carrier Protein
Format:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Formulation:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen:
PN:D324
Long Description:
Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain.1 A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified and its over-expression in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD.2 More recently, work has shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD.2,3 Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis.3 At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.
Target:
DEDD2

References

1. Tibbetts, MD. et al. (2003) Nat. Immunol. 4:404-9. 2. Roth, W. et al. (2002) J. Biol. Chem. 277:7501-8. 3. Alcivar, A. et al. (2003) Oncogene 22:291-7.