Leinco Technologies

Anti-Mouse LPAM-1 - Biotin

Product Code:
 
LEI-L294
Product Group:
 
Primary Antibodies
Host Type:
 
Rat
Antibody Isotype:
 
IgG2a κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
DATK32
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Flow Cytometry
Shipping:
 
2-8°C
Storage:
 
This biotinylated antibody is stable when stored at 2-8°C. Do not freeze.
 

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CodeSizePrice
LEI-L294-50ug50 ug£174.00
Quantity:
LEI-L294-200ug200 ug£227.00
Quantity:
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This product comes from: US.
Typical lead time: 14-21 working days.
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Further Information

Antigen Distribution:
LPAM-1 is expressed on most peripheral lymphocytes, subsets of thymocytes, and bone marrow progenitor cells.
Concentration:
0.5 mg/ml
Conjugate/Tag/Label:
Biotin
Format:
This biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Formulation:
This biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Immunogen:
TK1 Cells
Long Description:
LPAM-1 antibody, clone DATK32, recognizes mouse lymphocyte Peyer?s patch adhesion molecule (LPAM-1), also known as integrin alpha 4 beta 7 (α4β7). LPAM-1 is a heterodimer of the 154 kDa integrin α4 (CD49d) and 130 kDa integrin β7 chains and is a member of the Ig superfamily. LPAM-1 is expressed on most peripheral lymphocytes, subsets of thymocytes, and bone marrow hematopoietic stem cells1,2. LPAM-1 mediates adhesion to endothelial cells, promoting leukocyte transmigration across high endothelial venules (HEVs) during the inflammatory response. LPAM-1 binds to several ligands, including vascular adhesion molecule-1 (VCAM-1/CD106), mucosal addressin cell adhesion molecule-1 (MAdCAM-1), and fibronectin. MAdCAM-1 is expressed exclusively on endothelial cells of the gut and gut-associated lymphoid tissues, such as Peyer?s patches (PPs), and binding of LPAM-1 to MAdCAM-1 contributes to lymphocyte homing to mucosal tissues3,4. Vedolizumab, an anti-LPAM-1 monoclonal antibody, is approved to treat inflammatory bowel disease and effectively induces and maintains remission in Crohn's disease and ulcerative colitis5-8.
NCBI Gene:
311144
Target:
Integrin α4β7

References

1. Andrew DP, et al. (1996) Eur J Immunol. 26(4):897-905 2. Murakami JL, et al. (2016) Stem Cells Dev. 25(1):18-26 3. Hu MC, et al. (1992) Proc Natl Acad Sci USA. 89(17):8254-8 4. Hamann A, et al. (1994) J Immunol. 152(7):3282-93 5. Sandborn WJ, et al. (2013) N Engl J Med. 369:711?721 6. Feagan BG, et al. (2013) N Engl J Med. 369:699?710 7. Kopylov U, et al. (2019) Dig Liver Dis. 51:68?74 8. Danese S, et al. (2019) Gastroenterology.157:1007?1018 e1007