MBL

Anti-CD61 (GPIIIa) (Human) mAb

Product Code:
 
MBL-D281-3
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1 κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
T74
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Shipping:
 
4°C
Storage:
 
-20°C
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MBL-D281-3100 ul£296.00
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Further Information

Applications:
FCM - 1 ug/mL (final concentration)
Background:
Glycoprotein IIIa, a β3 (CD61) subunit of integrin αIIbβ3 (CD41/CD61), acts as a fibrinogen receptor on the platelet surface. A mouse monoclonal antibody, T74, recognizes human α3 (CD61) subunit and inhibits platelet aggregation induced by several agonists such as collagen, ADP, and thrombin. T74 inhibits clot-retraction mediated by platelets or αvβ3-expressing cells when induced by thrombin. Western-blot analysis is not possible. T74 fails to bind to platelets from patients with Glanzmann?s thrombasthenia.
Concentration:
1 mg/mL
Formulation:
100 ug IgG in 100 ul volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Immunogen Translated:
Human platelet
Reactivity:
It is reported that this clone (T74) recognizes human CD61 antigen in the reference number 1).
Shelf Life:
1 year
Source:
This antibody was purified from hybridoma (clone T74) supernatant using protein A agarose. This hybridoma was established by fusion of mouse myeloma cell NS-1 with Balb/c mouse splenocyte immunized with human platelet.
Target:
CD61

Documents

References

1) Katagiri, Y., et al., J. Biol. Chem. 270, 1785-1790 (1995) 2) Prandini, M. H., et al., Biochem. Biophys. Res. Commun. 156, 595-601 (1988) 3) Zimrin, A. B., et al., J. Clin. Invest. 81, 1470-1475 (1988) 4) Kunicki, T. J., et al., J. Clin. Invest. 67, 717-724 (1981) Clone T74 is used in the reference number 1).