MBL

Anti-FcmuR (TOSO/FAIM3) (Mouse) mAb

Product Code:
 
MBL-D303-3
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Rat
Antibody Isotype:
 
IgG1 κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
4B5
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Flow Cytometry
  • Immunocytochemistry (ICC)
Shipping:
 
4°C
Storage:
 
-20°C
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MBL-D303-3100 ul£442.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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  • Further Information
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Further Information

Applications:
FCM - 10 ug/mL (final concentration) ICC - 10 ug/mL
Background:
TOSO/Fas apoptotic inhibitory molecule 3 (FAIM3) was initially identified as an inhibitor for Fas-mediated apoptosis when overexpressed in T cells (1). The molecule has recently been identified as a Fc receptor for IgM (FcuR) both in humans and mice (2,3). FcuR/TOSO/FAIM3 is predominantly expressed in B lymphocyte lineage cells (2,3). In humans, FcuR/TOSO/FAIM3 is also expressed on T cells (2). Chronic lymphocytic leukemia cells are reported to express increased levels of FcuR/TOSO/FAIM3 compared to healthy B cells (4), and that its expression in the leukemia cells is controlled by B-cell receptor signaling (5). These observations may suggest a role for FcuR/TOSO/FAIM3 in BCR signaling and/or B-cell activation.
Concentration:
1 mg/mL
Formulation:
1 mg/mL in PBS containing 50% Glycerol (pH 7.2). No preservative is contained.
Gene IDs:
Mouse: 69169
Immunogen Translated:
Extracellular domain of the receptor mouse Fcu, Fc fusion protein
Shelf Life:
1 year
Source:
Purified IgG from hybridoma supernatant

Documents

References

1) Hitoshi, Y., et al., Immunity. 8, 461-471 (1998) 2) Kubagawa, H., et al., J. Exp. Med. 206, 2779-2793 (2009) 3) Shima, H., et al., Int. Immunol. 22, 149-156 (2010) [FCM] 4) Proto-Siqueira, R., et al., Blood 112, 394-397 (2008) 5) Pallasch, C. P., et al., Blood 112, 4213-4219 (2008)