MBL

Anti-Fas (CD95) (Human) mAb

Product Code:
 
MBL-MD-11-3
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
ZB4
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Flow Cytometry
  • Neutralisation
  • Western Blot (WB)
Shipping:
 
4°C
Storage:
 
-20°C
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MBL-MD-11-3100 ug£345.00
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  • Further Information
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Further Information

Applications:
WB - 5 ug/mL (chemiluminescence detection system) FCM - 5-20 ug/mL (final concentration) NT - 10-500 ng/mL
Background:
It is now widely accepted that apoptosis plays an important role in the selection of immature thymocytes and Ag-primed peripheral T cells. Fas (also known as CD95/APO-1) is a cell surface protein belonging to the tumor necrosis factor receptor superfamily, which is expressed in a variety of normal and neoplastic cells. Binding of FasL to Fas or crosslinking of Fas by anti-Fas monoclonal antibodies results in rapid induction of apoptosis in Fas expressing cells. Clone ZB4 is known as Fas blocking, Fas neutralizing or Fas antagonistic antibody, whereas anti-Fas antibody (clone CH-11) is known as the agonistic antibody.
Concentration:
1 mg/mL
Formulation:
100 ug IgG in 100 ul volume of PBS containing 1% BSA and 0.09% NaN3.
Gene IDs:
Human: 355 Mouse: 14102
Immunogen Translated:
Recombinant human Fas
Reactivity:
This antibody reacts with human Fas on Western blotting and Flow cytomet ry. It does not react with mouse Fas.
Shelf Life:
1 year
Source:
This antibody was purified from hybridoma (clone ZB4) supernatant using protein A agarose. This hybridoma was established by fusion of mouse myeloma cell NS-1 with Balb/c mouse splenocyte immunized with recombinant human Fas.
Target:
Fas

Documents

References

1) Arokium, H., et al., J. Virol. 83, 11283-11297 (2009) 2) Giammarioli, A. M., et al., Cancer Res. 68, 5291-5300 (2008) 3) Schumann, D. M., et al., PNAS 104, 2861-2866 (2007) 4) Maedler, K., et al., Diabetes 55, 2713-2722 (2006) 5) Gilhar, A., et al., Am. J. Pathol. 168, 170-175 (2006) 6) Ito, K., et al., Cancer Res. 65, 4417-4424 (2005) 7) Ahmed, F., et al., Blood 103, 2079-2087 (2004) 8) Holler, N., et al., Mol. Cell. Biol. 23, 1428- 1440 (2003) 9) Maedler, K., et al., PNAS 99, 8236-8241 (2002) 10) Maedler, K., et al., Diabetes 50, 1683-1690 (2001) 11) Jiang, S., et al., Invest. Ophthalmol. Vis. Sci. 41, 645-655 (2000) 12) Landowski, T. H., et al., Blood 94, 265-274 (1999) 13) Agrawal, S., et al., J. Clin. Invest. 102, 1715-1723 (1998) 14) Giordano, C. et al., Science 275, 960-963 (1997) 15) Boirivant, M., et al., J. Clin. Invest. 98, 2616-2622 (1996) As clone ZB4 is really famous all over the world, a lot of researches have been reported. These references are a part of such reports.