Anti-MBP (Myelin Basic Protein) pAb

WB - 1:200-1:1,000 (chemiluminescence detection system)

Myelin basic protein (MBP) is a hydrophilic, ~33 kDa homodimer that accounts for about 30 percent of the proteins in the myelin sheath of the central nervous system, where it plays a role in both its formation and stabilization. At least 6 different MBP isoforms are produced by alternative splicing. MBP is expressed in oligodendrocytes, the myelin of white matter in the brain and spinal cord, and in peripheral nerves. It is expressed less abundantly in grey matter. MBP is the target of many post-translational modifications, including N-terminal acetylation, Arg methylation, phosphorylation by Ser/Thr kinases, and Gln deamidation. The incidence of MBP autoantibody in the autistic population is significantly higher than that of the normal population; hence, it serves as a primary marker of the autoimmune reaction in autism. Altered MBP levels and MBP autoantibodies are also associated with Multiple Sclerosis, Alzheimer's disease, ALS, and peripheral neuropathy.

100 ul volume of PBS containing 50% glycerol, pH 7.2. Contains no preservative.

Human: 4155 Mouse: 17196

MBP peptide was added at the end of the cysteine ??C (19-STMDHARHGF LP-30)

This antibody reacts with human, mouse and rat MBP.

1 year

This antibody is a rabbit polyclonal antibody against the MBP peptide with the C-terminal cysteine extension (19-STMDHARHGFLP-30). The IgG was fractioned by salting out and gel filtration on a Sephadex G-20°0 column.

MBP