MBL

Anti-Beclin 1 (Human) pAb

Product Code:
 
MBL-PD017
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Hamster
  • Human
  • Mouse
  • Rat
Applications:
  • Immunocytochemistry (ICC)
  • Immunoprecipitation (IP)
  • Western Blot (WB)
Shipping:
 
4°C
Storage:
 
-20°C
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MBL-PD017100 ug£318.00
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  • Further Information
  • Documents
  • References
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Further Information

Applications:
WB - 1:1000 IP - 2.5 uL/200 uL of cell extract from 5x106 cells ICC - 1:100
Background:
Autophagy is a process of intracellular bulk degradation in which cytoplasmic components including organelles are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. Beclin 1, the mammalian homologue of yeast Atg6, was first identified Bcl-2-interacting protein. Beclin 1 localizes to the trans-Golgi network, and forms a complex with phosphatidylinositol 3-kinase. Beclin 1 is essential for early autophagosome formation.
Formulation:
In PBS/50% glycerol, pH 7.2
Gene IDs:
Human: 8678 Mouse: 56208
Immunogen Translated:
Full-length recombinant human Beclin 1
Reactivity:
This antibody reacts with Beclin 1 on Western blotting, Immunoprecipitation and Immunocytochemistry.
Shelf Life:
1 year
Source:
This antibody was purified from rabbit serum using affinity column. The rabbit was immunized with the recombinant full-length human Beclin 1.
Target:
Beclin 1

Documents

References

1) Hamasaki, M., et al., Nature 495, 389-393 (2013) [WB] 2) Berliocchi, L., et al., Mol. Pain 7, 83 (2011) [WB] 3) Russo, R., et al., Cell Death Dis. 2, e144 (2011) [WB, IHC] 4) Matsunaga, K., et al., J. Cell Biol. 190, 511-521 (2010) [WB] 5) Yu, L., et al., Science 304, 1500-1502 (2004) 6) Kihara, A., et al., EMBO Rep. 2, 330-335 (2001) 7) Liang, X. H., et al., Nature 402, 672-676 (1999) 8) Liang, X. H., et al., J. Virol. 72, 8586-8596 (1998)