Elabscience

SARM1 Polyclonal Antibody

Product Code:
 
E-AB-92292
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunoprecipitation (IP)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze/thaw cycles.
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Western blot analysis of extracts of various cell lines using SARM1 Polyclonal Antibody at 1:1000 dilution.
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Immunoprecipitation analysis of 300ug extracts of SH-SY5Y cells using 3ug SARM1 Polyclonal Antibody.Western blot was performed from the immunoprecipitate using SARM1 Polyclonal Antibody at a dilution of 1:1000.
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Western blot analysis of extracts of various cell lines using SARM1 Polyclonal Antibody at 1:1000 dilution.
Immunoprecipitation analysis of 300ug extracts of SH-SY5Y cells using 3ug SARM1 Polyclonal Antibody.Western blot was performed from the immunoprecipitate using SARM1 Polyclonal Antibody at a dilution of 1:1000.

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E-AB-92292-60uL60uL£210.00
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E-AB-92292-120uL120uL£291.00
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E-AB-92292-200uL200uL£431.00
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Further Information

Abbreviation:
SARM1
Background:
NAD(+ hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+ metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+ depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+ into ADP-D-ribose (ADPR, cyclic ADPR (cADPR and nicotinamide; NAD(+ cleavage promoting cytoskeletal degradation and axon destruction. Also able to hydrolyze NADP(+, but not other NAD(+-related molecules. Can activate neuronal cell death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity. Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.
Buffer:
PBS with 0.05% proclin300,50% glycerol,pH7.3.
Calculated MW:
79kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000,IP 1:50-1:200
Immunogen:
A synthetic peptide of human SARM1
ObservedMW:
73KDa
Purification method:
Affinity purification
Target Synonym:
SARM; HsTIR; SAMD2; hSARM1; MyD88-5
UNIProt ID:
Q6SZW1

Documents