ACE Antibody

Western blot: 1:500-1:16000

Titration of the ACE antibody may be required due to differences in protocols and secondary/substrate sensitivity.

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active.

Ascites

In ascites with 0.09% sodium azide

A portion of amino acids 1274-1306 from the human protein was used as the immunogen for this ACE antibody.

This ACE antibody is available for research use only.

Ascites

P12821