TargetMol

PPTN hydrochloride

Product Code:
 
TAR-T63534
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T63534-1mg1mg£103.00
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TAR-T63534-5mg5mg£148.00
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TAR-T63534-10mg10mg£201.00
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TAR-T63534-25mg25mg£329.00
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TAR-T63534-50mg50mg£470.00
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TAR-T63534-100mg100mg£651.00
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Quantity:
TAR-T63534-500mg500mg£1,291.00
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Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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  • Further Information
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Further Information

Bioactivity:
PPTN hydrochloride is a potent, high-affinity, competitive, highly selective P2Y14 receptor antagonist (KB: 434 pM), but no agonist or antagonist activity at P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12 or P2Y13 receptors, exhibiting anti-inflammatory and anti-immune effects.
CAS:
1992047-65-0
Molecular Weight:
511.96
Pathway:
Neuroscience|GPCR/G Protein
Purity:
0.9994
SMILES:
Cl.O=C(O)C1=CC2=CC(=CC=C2C(=C1)C3=CC=C(C=C3)C4CCNCC4)C=5C=CC(=CC5)C(F)(F)F
Target:
P2Y Receptor

Documents

References

Barrett MO, et al. A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol Pharmacol. 2013 Jul;84(1):41-9. Lin J, et al. The P2Y14 receptor in the trigeminal ganglion contributes to the maintenance of inflammatory pain. Neurochem Int. 2019 Dec;131:104567.