TargetMol

Sunvozertinib

Product Code:
 
TAR-T64124
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T64124-1mg1mg£119.00
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TAR-T64124-5mg5mg£189.00
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TAR-T64124-10mg10mg£262.00
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TAR-T64124-25mg25mg£454.00
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TAR-T64124-50mg50mg£623.00
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TAR-T64124-100mg100mg£858.00
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TAR-T64124-500mg500mg£1,645.00
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This product comes from: United States.
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Further Information

Bioactivity:
Sunvozertinib is a potent ErbBs and BTK inhibitor and has inhibitory effects on EGFR, Her2 and mutant epidermal growth factor. Sunvozertinib showed inhibition of EGFR exon 20 NPH insertion, EGFR exon 20 ASV insertion, EGFR L858R and T790M mutation, and Her2 exon 20 YVMA and EGFR WT A431. IC50 were 20.4, 20.4, 1.1, 7.5 and 80.4 nM, respectively.
CAS:
2370013-12-8
Molecular Weight:
584.09
Pathway:
Angiogenesis|Tyrosine Kinase/Adaptors|JAK/STAT signaling
Purity:
0.9811
SMILES:
N(C(C=C)=O)C1=C(C=C(OC)C(NC=2N=C(NC3=C(C(C)(C)O)C=C(F)C(Cl)=C3)C=CN2)=C1)N4C[C@H](N(C)C)CC4
Target:
BTK|EGFR

Documents

References

Zhengtao LI, et al. Erbb/btk inhibitors. WO2019149164A1.