TargetMol

NRX-0492

Product Code:
 
TAR-T75133
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
 

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CodeSizePrice
TAR-T75133-50mg50mgEnquire
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TAR-T75133-5mg5mgEnquire
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
NRX-0492 is an orally active and potent degrader of BTK . NRX-0492 catalyzes ubiquitylation and proteasomal degradation of BTK with DC 50 ≤0.2 nM and DC 90 ≤0.5 nM, respectively. NRX-0492 inhibits B-cell receptor (BCR)-mediated signaling, transcriptional programs, and chemokine secretion. Moreover, NRX-0492 also links a noncovalent BTK-binding domain to Cereblon . Cereblon is an adaptor protein of the E3 ubiquitin ligase complex [1] .
CAS:
2416130-57-7
Molecular Weight:
817.94
Purity:
0.98

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