TargetMol

Rolofylline

Product Code:
 
TAR-T16782
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-T16782-100mg100mg£418.00
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This product comes from: United States.
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Further Information

Bioactivity:
Rolofylline is an effective and selective adenosine A1 receptor antagonist. Rolofylline is metabolized primarily to the pharmacologically active M1-trans and M1-cis metabolites by cytochrome P450.
CAS:
136199-02-5
Formula:
C20H28N4O2
Molecular Weight:
356.46
Purity:
0.98
SMILES:
O=C1C=2NC(=NC2N(C(=O)N1CCC)CCC)C34CC5CC(CC3C5)C4

Documents

References

Dennissen FJ, et al. Adenosine A1 receptor antagonist rolofylline alleviates axonopathy caused by human Tau ?K280. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11597-11602. Epub 2016 Sep 26. Stroh M, et al. Simultaneous pharmacokinetic model for rolofylline and both M1-trans and M1-cis metabolites. AAPS J. 2013 Apr;15(2):498-504.