TargetMol

cGAMP disodium

Product Code:
 
TAR-T13606L
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
cGAMP disodium is a cyclic dinucleotide (CDN) found in bacteria that acts as an endogenous second messenger affecting interferon production in response to cytoplasmic DNA. cGAMP disodium cascades signals from type I interferons and other immune mediators by activating interferon gene stimulator (STING). cGAMP disodium is a potent sublingual immune adjuvant that enables better immune function (serum anti-PA neutralization and airway secretions anti-PA SIgA response).
CAS Number:
2407516-83-8
Formula:
C20H24N10O13P2.2Na
Molecular Weight:
720.39
Purity:
98%
SMILES:
O[C@H]1[C@@H](O[C@@]2([H])[C@@]1([H])OP(O)(OC[C@]3([H])[C@@]([C@H]([C@H](N4C5=NC=NC(N)=C5N=C4)O3)O)([H])OP(O)(OC2)=O)=O)N6C7=C(C(N=C(N7)N)=O)N=C6.[Na].[Na]

Documents

References

1.Jiaxi Wu, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339(6121):826-30. 2.Ivana Skrnjug , et al. Cyclic GMP-AMP displays mucosal adjuvant activity in mice. PLoS One. 2014 Oct 8;9(10):e110150. 3.Andrea Ablasser, et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503(7477):530-4.