Ionomycin

Product Code:

TAR-T7285

Product Group:

Natural Products and Extracts

Supplier:

TargetMol

Regulatory Status:

RUO

Shipping:

cool pack

Storage:

-20°C

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Code	Size	Price

TAR-T7285-1mg

1mg

£228.00

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Quantity:

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Further Information

Bioactivity:

Ionomycin is an calcium ionophore and an antibiotic that binds calcium ions (Ca2+). It is produced by the bacterium Streptomyces conglobatus.It is used in research to raise the intracellular calcium level (Ca2+) and as a research tool to understand Ca2+ transport across biological membranes. Ionomycin promotes apoptosis and induces the activation of protein kinase C (PKC).

CAS Number:

56092-81-0

Formula:

C41H72O9

Molecular Weight:

709.01

Purity:

100%

SMILES:

C[C@@]1(O[C@H](C[C@@H]([C@@H]([C@@H]([C@@H](/C=C/C[C@H](C[C@H](/C(=C/C([C@H](C[C@H](C[C@@H](CCC(O)=O)C)C)C)=O)/O)C)C)C)O)C)O)CC1)[C@@]2(O[C@@]([C@@H](C)O)(C)CC2)[H]

Target:

Calcium Channel

Documents

References

1.Lautens M, et al. Total synthesis of ionomycin using ring-opening strategies. Org Lett. 2002 May 30;4(11):1879-82. 2.Assfalg-Machleidt I,et al. Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members. J Biol Chem. 2002 Jul 26;277(30):27217-26. 3.Uwada J, et al. Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-? signalling in the intestinal epithelial cells. Cell Signal. 2019 Nov;63:109358.