TargetMol

Harzianopyridone

Product Code:
 
TAR-TN7266
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
 

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CodeSizePrice
TAR-TN7266-10mg10mgEnquire
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TAR-TN7266-50mg50mgEnquire
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Further Information

Bioactivity:
Harzianopyridone is an atpenin-like compound that functions as an inhibitor of mammalian and nematode mitochondrial complex II, also known as succinate:ubiquinone oxidoreductase (SQR), demonstrating IC50 values of 0.017, 0.2, and 2 uM against bovine, rat, and nematode complex II, respectively. Additionally, it inhibits nematode quinol-fumarate reductase (QFR) with an IC50 value of 0.36 uM. Significantly selective for complex II over complexes I and III in rats and cattle, as well as complex I in nematodes, with IC50 values exceeding 100 uM, it exhibits notable antibacterial and antifungal properties, with EC50 values of 35.9, 42.2, 60.4, and 50.2 ug/ml against R. solani, S. rolfsii, M. phaseolina, and F. oxysporum, respectively.
CAS Number:
137813-88-8
Formula:
C14H19NO5
Molecular Weight:
281.308
Purity:
98%
SMILES:
COc1[nH]c(=O)c(C(=O)[C@@H](C)C\C=C\C)c(O)c1OC

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