TargetMol

Araguspongin B

Product Code:
 
TAR-TN7278
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
 

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CodeSizePrice
TAR-TN7278-10mg10mgEnquire
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TAR-TN7278-50mg50mgEnquire
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Further Information

Bioactivity:
Xestospongins and araguspongins, marine natural products originally isolated from sponges in the Pacific basin, exhibit vasodilatory effects. Inositol phosphates (IP) serve as crucial signal transduction messengers, activating IP3 receptors to facilitate Ca2+ release from intracellular stores. Araguspongin B specifically hinders the calcium-releasing function of inositol 1,4,5-trisphosphate at the receptor level within cerebral microsomes, demonstrating an inhibition concentration (IC50) of 0.6 uM. This potency places it nearly on par with xestospongin C in obstructing the IP3 receptor's activity.
CAS Number:
123000-02-2
Purity:
98%

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