MBL

Anti-CD112 (Nectin-2) (Mouse) mAb

Product Code:
 
MBL-D083-3
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Rat
Antibody Isotype:
 
IgG2a κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
502-57
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Immunocytochemistry (ICC)
Shipping:
 
4°C
Storage:
 
-20°C
 

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MBL-D083-3100 ug£327.00
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Further Information

Applications:
ICC - 5-10 ug/mL
Background:
Nectins are Ca2+-independent immunoglobulin-like cell-cell-adhesion molecules. Nectins comprise a family of four members: nectin-1 (CD111/PRR-1), nectin-2 (CD112/PRR-2), nectin-3 (CD113/PRR-3), and nectin-4. Nectin-2 and -3 are ubiquitously expressed whereas nectin-1 is abundantly expressed in brain. Nectin-2 is a ligands for CD226 (DNAM-1) which is an adhesion molecule involved in NK and T cell-mediated cytotoxicity against certain tumors.
Concentration:
1 mg/ml
Formulation:
100 ug IgG in a 100 ul volume of PBS containing 50% glycerol, pH 7.2. Contains nopreservatives.
Gene IDs:
Human: 5819 Mouse: 19294
Immunogen Translated:
Mouse recombinant extracellular domain fusion protein value Kuching 2 (1-338a.a.)-Fc
PM_Meta_Key:
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PM_Meta_Value:
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Reactivity:
This antibody reacts with mouse CD112 antigen on Immunocytochemistry.
Shelf Life:
1 year
Source:
This antibody was purified from hybridoma (clone 502-57) supernatant using protein G agarose. This hybridoma was established by fusion of mouse myeloma cell P3U1 with Wister Rat B-lymphocyte immunized with the recombinant mouse Nectin-2 extra cellular region-Fc fusion protein (1-338 aa.).
Target:
Nectin 2

Documents

References

1) Inagaki, M., et al., Genes Cells 11, 1125-1132 (2006) 2) Inagaki, M., et al., Development 132, 1525-1537 (2005) 3) Guttman, J. A., et al., Biol. Reprod 71, 548-559 (2004) 4) Mizoguchi, A., et al., J. Cell Biol. 156, 555-565(2002) 5) Miyashita, M., et al., J. Biol. Chem. 275, 613-618 (2000) 6) Horikawa, S. K., et al., J. Biol. Chem. 275, 10291-10299 (2000) 7) Takahashi, K., et al., J. Cell Biol. 145, 539-549 (1999) Clone 502-57 is used in these references.