TargetMol

VAV1 degrader-3

Product Code:
 
TAR-T201392
Product Group:
 
Peptides
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
 

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TAR-T201392-1mg1mgEnquire
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TAR-T201392-5mg5mgEnquire
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This product comes from: Austria.
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Further Information

Bioactivity:
VAV1 degrader-3 is a molecular gel degrader targeting VAV1 with a DC50 of 7 nM. VAV1 is a key signaling protein downstream of T cell and B cell receptors. VAV1 degrades VAV1 to degrader-3, which significantly reduces the level of cytokines associated with immune-mediated diseases, but has no effect on other proteins, and can be used to study inflammatory or autoimmune diseases.In mouse models of various diseases, such as experimental autoimmune encephalomyelitis (EAE), colitis, and collagen-induced arthritis (CIA), VAV1 degraders the progression of disease.
CAS Number:
3050683-38-7
Formula:
C22H17ClN2O3
Molecular Weight:
392.83
SMILES:
O=C1CCC(C2=CC=CC(C3=CC=C(N4C=CC=CC4=O)C=C3)=C2Cl)C(=O)N1