Human HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Tetramer Protein (MHC-HM411T)
Product Code:
KAC-MHC-HM411T
Shipping:
Shipped at ambient temperature.
Storage:
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
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Immobilized Human HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Tetramer, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Anti-HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Antibody, hFc Tag with the EC50 of 5.0ng/ml determined by ELISA
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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Further Information
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of malignant tumors that highly express LMP2.
no
Recombinant Human HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus,tetramer is assembled by biotinylated monomer and streptavidin.It contains Gly25-Thr305 (HLA-A*02:01), Ile21-Met119 (B2M) and CLGGLLTMV peptide.
Less than 1EU per ug by the LAL method.
Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and CLGGLLTMV peptide
HEK293
Lyophilized
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
A0A140T913(HLA-A*02:01)&P61769(B2M)&CLGGLLTMV
The protein has a predicted MW of 258 kDa. Due to glycosylation, the protein migrates to 260-265 kDa under Non reducing (N) condition based on Bis-Tris PAGE result.
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
MHC; RMF; LMP2; LMP-2; Macropain chain 7; Proteasome chain 7; PSMB9; RING12
C-His-Avi
HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Tetramer
