Applied Biological Materials Inc.

dCas9-DNMT3A Lentivirus

Product Code:
 
ABM-K092
Regulatory Status:
 
RUO
Shipping:
 
Dry ice
Storage:
 
-80°C

 

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ABM-K0924 x 500ul£667.00
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This product comes from: Canada.
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Further Information

Description:
This construct consists of the catalytic domain of DNA methyltransferase (DNMT3A) fused to the C-terminus of Cas9 Double Mutant (dCas9). The Cas9 Double Mutant has changes at amino acid positions D10A and H840A which completely inactivate both nuclease and nickase activities. The DNMT3A domain facilitates CpG site methylation leading to transcriptional down-regulation. By using specific sgRNAs, the dCas9-DNMT3A can be targeted to a promoter region allowing for epigenetic control over the expression of almost any gene of interest.