Chemodex

Fluconazole

Product Code:
 
CDX-F0104
Product Group:
 
Other Biochemicals
Supplier:
 
Chemodex
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short term: +20°C. Long term: +20°C
Chemical Structure

Chemical Structure 

No additional charges, what you see is what you pay! *

CodeSizePrice
CDX-F0104-M500500 mg£52.00
Quantity:
CDX-F0104-G0011 g£75.00
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges to UK mainland customers, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: Switzerland.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Show All

Further Information

Appearance:
White crystalline powder.
CAS:
86386-73-4
Description:
Fluconazole is a triazole broad-spectrum antifungal agent which is effective against most Candida spp. cryptococcus neoformans and dermatophytes. Fluconazole is an inhibitor of CYP2C19, CYP2C9 and CYP3A4. Fluconazole functions by suppressing the production of ergosterol, a vital constituent of the fungal cell membrane. By impeding ergosterol synthesis, the integrity of the fungal cell membrane is compromised, ultimately resulting in fungal death. Moreover, Fluconazole hinders the activity of cytochrome P450 enzymes.
EClass:
32160000
Form:
solid
GHS:
GHS07, GHS08
Handling Advice:
Protect from light and moisture.
Hazards:
H302-H360D-H362-H412
InChi:
InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2
InChi Key:
RFHAOTPXVQNOHP-UHFFFAOYSA-N
MDL:
MFCD00274549
Molecular Formula:
C13H12F2N6O
Molecular Weight:
306.27
Package Type:
Vial
Precautions:
P202-P260-P263-P273-P301 + P312-P308 + P313
Purity:
>98% (HPLC)
Signal word:
Danger
SMILES:
FC1=CC(F)=C(C(CN2C=NC=N2)(O)CN3N=CN=C3)C=C1
Solubility:
Soluble in DMSO (10mg/ml), ethanol (10mg/ml), methanol or acetone.
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at RT.

Documents

References

(1) M.S. Saag & W.E. Dismukes; Antimicrob. Agents Chemother. 32, 1 (1988) | (2) H. Washton; Diagn. Microbiol. Infect. Dis. 12, 229S (1989) | (3) D.W. Warnock; J. Antimicrob. Chemother. 24, 275 (1989) | (4) K. Richardson, et al.; Rev. Infect. Dis. 12, S267 (1990) | (5) S.F. Kowalsky & D.M. Dixon; Clin. Pharm. 10, 179 (1991) | (6) J.D. Morrow; Am. J. Med. Sci. 302, 129 (1991) | (7) C.M. Perry, et al.; Drugs 49, 984 (1995) | (8) M.V. Martin; J. Antimicrob. Chemother. 44, 429 (1999) | (9) N. Thamban Chandrika, et al.; Bioorg. Med. Chem. 26, 573 (2018) | (10) S. Nami, et al.; Biomed. Pharmacother. 110, 857 (2019) | (11) X. Heng, et al.; Antimicrob. Agents Chemother. 65, e02552 (2021) | (12) M.A Elzoheiry, et al.; Exp. Parasitol. 239, 108291 (2022)