Chemodex

Fusidic acid

Product Code:
 
CDX-F0226
Product Group:
 
Other Biochemicals
Supplier:
 
Chemodex
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short term: +20°C. Long term: +4°C
Chemical Structure

Chemical Structure 

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CDX-F0226-G0011 g£191.00
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This product comes from: Switzerland.
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  • Further Information
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Further Information

Appearance:
White to off-white powder.
CAS:
03.06.6990
Description:
The tetracyclic triterpenoid is a fusidane antibiotic originally isolated from F. coccineum. It is active against the Gram-positive bacteria S. aureus, S. pyogenes, C. diphtheriae, B. subtilis, and C. tetani but not the Gram-negative bacteria E. coli, S. typhimurium, and P. vulgaris or the fungi C. albicans and A. fumigatus. This antibacterial agent inhibits bacterial protein synthesis by preventing the release of translation elongation factor G (EF-G) from ribosomes. Fusidic acid has immunomodulatory effects and inhibits the inhibitory and activating effects of interleukins IL-1 and IL-6 on glucose-induced insulin production and exhibits antidiabetic effects in a rat model. Fusidic acid improves the symptoms of colitis in rats and inhibits the growth of Toxoplasma gondii and Listeria monocytogenes EGD in vitro, but not in mice.
EClass:
32160000
Form:
solid
GHS:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H302
InChi:
InChI=1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1
InChi Key:
IECPWNUMDGFDKC-MZJAQBGESA-N
MDL:
MFCD00865135
Molecular Formula:
C31H48O6
Molecular Weight:
516.71
Package Type:
Vial
Precautions:
P264-P270-P301 + P312 + P330-P501
Purity:
>98% (TLC)
Signal word:
Warning
SMILES:
OC(/C(CC/C=C(C)/C)=C1[C@@H](OC(C)=O)C[C@]2(C)[C@@]3(C)CC[C@@]4([H])[C@H](C)[C@H](O)CC[C@]4(C)[C@]3([H])[C@H](O)C[C@]2\1[H])=O
Solubility:
Soluble in ethanol (20mg/ml), DMSO or chloroform.
Source / Host:
Microbial
Transportation:
Non-hazardous
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.

Documents

References

(1) W.O. Godtfredsen, et al.; Nature 193, 987 (1962) | (2) N. Tanaka, et al.; Biochem. Biophys. Res. Commun. 30, 278 (1968) | (3) L. Verbist; J. Antimicrob. Chemother. 25, 1 (1990) | (4) K. Bendtzen, et al.; J. Endocrinol. 132, 345 (1992) | (5) K. Buschard, et al.; Autoimmunity 14, 101 (1992) | (6) J Turnidge, et al.; Int. J. Antimicrob. Agents 12, S23 (1999) | (7) P. Collignon & L. Turnidge; Int. J. Antimicrob. Agents 12, S45 (1999) | (8) K. Christiansen; Int. J. Antimicrob. Agents 12, S73 (1999) | (9) A. Savelsbergh, et al.; RNA 15, 772 (2009)