Chemodex

7-Fluoro-2,1,3- benzoxadiazole-4-sulfonylchloride

Product Code:
 
CDX-F0577
Product Group:
 
Dyes, Stains, and Probes
Supplier:
 
Chemodex
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short term: +4°C. Long term: -20°C
Chemical Structure

Chemical Structure 

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CDX-F0577-M05050 mg£127.00
Quantity:
CDX-F0577-M100100 mg£446.00
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  • Further Information
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Further Information

Appearance:
Light orange solid.
CAS:
91366-64-2
Description:
4-(Chlorosulfonyl)-7-fluoro-2,1,3-benzoxadiazole is a versatile nucleophilic intermediate or building block for the synthesis of thiol-reactive fluorogenic probes, like ADB-F, SBD-F or DBD-F. It is characterized by its unique chlorosulfonyl group that enhances electrophilic reactivity. The presence of the fluorine atom increases the compound's polarity, promoting strong dipole interactions. This compound exhibits rapid reaction kinetics, particularly in nucleophilic substitution reactions, making it an intriguing subject for exploring mechanistic pathways and reactivity profiles in synthetic chemistry.
EClass:
32160000
Form:
solid
GHS:
GHS05
Handling Advice:
Protect from light and moisture.
Hazards:
H314, H318
InChi:
InChI=1S/C6H2ClFN2O3S/c7-14(11,12)4-2-1-3(8)5-6(4)10-13-9-5/h1-2H
InChi Key:
ULAADSMIEGGGMT-UHFFFAOYSA-N
MDL:
MFCD03425535
Molecular Formula:
C6H2ClFN2O3S
Molecular Weight:
236.61
Package Type:
Vial
PG:
II
Precautions:
P280, P303+P361+P353, P305+P351+P338
Purity:
>95% (NMR)
Signal word:
Danger
SMILES:
FC1=CC=C(S(=O)(Cl)=O)C2=NON=C21
Solubility:
Soluble in DMSO or chloroform.
Source / Host:
Synthetic
Transportation:
Excepted Quantity
UN Nummer:
UN3261
UNSPSC Number:
41105331
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

Documents

References

(1) T. Toyo'oka & K. Imai; Anal. Chem. 56, 2461 (1984) | (2) T. Toyo'oka, et al.; Analyst 114, 413 (1989) | (3) T. Toyo'oka, et al.; Analyst 114, 1233 (1989) | (4) T. Kajiro, et al.; Analyst 125, 1115 (2000) | (5) K. Okabe, et al.; J. Chromatogr. A 982, 111 (2002)