Chemodex

Hydrocortisone

Product Code:
 
CDX-H0269
Product Group:
 
Other Biochemicals
Supplier:
 
Chemodex
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short term: +20°C. Long term: +20°C
Chemical Structure

Chemical Structure 

No additional charges, what you see is what you pay! *

CodeSizePrice
CDX-H0269-G0011 g£52.00
Quantity:
CDX-H0269-G0055 g£104.00
Quantity:
CDX-H0269-G02525 g£290.00
Quantity:
Prices exclude any Taxes / VAT
Stay in control of your spending. These prices have no additional charges to UK mainland customers, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: Switzerland.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Show All

Further Information

Appearance:
White to off-white powder.
CAS:
50-23-7
Description:
Hydrocortisone is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH). Hydrocortisone has three times the anti-inflammatory potency of corticosterone but much lower Na+ retention potency. It is an agonist at the mineralocorticoid receptor (MR) and the glucocorticoid receptor. Hydrocortisone plays a role in the regulation of metabolism, electrolyte balance, water balance, and the body's stress response. Hydrocortisone production is increased during periods of stress, and it is a major effector molecule in the hypothalamic-pituitary-adrenal axis (HPA) stress response. Cortisol levels increase with age and are often elevated in major depressive disorder, certain forms of hypertension, and Parkinson's disease. It has been utilized in research to investigate the impact of inflammation and stress on cellular processes.
EClass:
32160000
Form:
solid
GHS:
GHS08
Handling Advice:
Protect from light and moisture.
Hazards:
H360Df-H373
InChi:
InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChi Key:
JYGXADMDTFJGBT-VWUMJDOOSA-N
MDL:
MFCD00011654
Molecular Formula:
C21H30O5
Molecular Weight:
362.46
Package Type:
Vial
Precautions:
P202-P260-P280-P308 + P313-P405-P501
Purity:
>98% (HPLC)
Signal word:
Danger
SMILES:
O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)=C1
Solubility:
Soluble in DMSO (20mg/ml).
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at RT.

Documents

References

(1) D.T. Matulich, et al.; J. Clin. Endocrinol. Metab. 43, 1170 (1976) | (2) P.E. Stokes; Eur. Neuropsychopharmacol. 5, 77 (1995) | (3) F.P. Varghese & E.S. Brown; Prim. Care Companion. J. Clin. Psychiatry 3, 151 (2001) | (4) M. Quinkler & P.M. Stewart; J. Clin. Endocrinol. Metab. 88, 2384 (2003) | (5) J. Nijm & L. Jonasson; Ann. Med. 41, 224 (2009) | (6) S. Paredes & L. Ribeiro; Rev. Assoc. Med. Bras. 60, 84 (2014) | (7) D.J. van Wamelen, et al.; Int. Rev. Neurobiol. 152, 131 (2020)