Chemodex

(2-Hydroxypropyl)-beta-cyclodextrin

Product Code:
 
CDX-H0352
Product Group:
 
Other Biochemicals
Supplier:
 
Chemodex
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short term: +20°C. Long term: +20°C
Chemical Structure

Chemical Structure 

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CDX-H0352-G02525 g£104.00
Quantity:
CDX-H0352-G100100 g£214.00
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This product comes from: Switzerland.
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  • Further Information
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Further Information

Appearance:
White to off-white powder.
CAS:
128446-35-5
Description:
2-Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) is a cyclic oligosaccharide containing seven D-(+)-glucopyranose units that is widely used to improve the aqueous solubility of various compounds, especially those containing a phenyl group. The circular arrangement of its glucose units produces a torus-shaped ring configuration in which the CH2 groups and ether linkages of the molecule face the hollow interior, resulting in a nonpolar, hydrophobic cavity and a polar, hydrophilic exterior. When combined in solution with other compounds, the nonpolar aromatic portions of that compound interact with the nonpolar interior of the HP-beta-CD molecule, thus isolating the aromatic portion of the molecule from the water and thereby increasing its aqueous solubility. HP-beta-CD is a mixture containing HP-beta-CD with variable hydroxypropyl group substitutions and is a widely used drug delivery vehicle to improve the stability and bioavailability of bioactive compounds. HP-beta-CD is also a cholesterol modifier and has shown anticancer activity.
EClass:
32160000
Form:
solid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C63H112O42/c1-22(64)8-85-15-29-50-36(71)43(78)57(92-29)100-51-30(16-86-9-23(2)65)94-59(45(80)38(51)73)102-53-32(18-88-11-25(4)67)96-61(47(82)40(53)75)104-55-34(20-90-13-27(6)69)98-63(49(84)42(55)77)105-56-35(21-91-14-28(7)70)97-62(48(83)41(56)76)103-54-33(19-89-12-26(5)68)95-60(46(81)39(54)74)101-52-31(17-87-10-24(3)66)93-58(99-50)44(79)37(52)72/h22-84H,8-21H2,1-7H3/t22?,23?,24?,25?,26?,27?,28?,29-,30-,31?,32?,33?,34?,35?,36?,37-,38?,39-,40+,41+,42+,43?,44+,45?,46+,47+,48+,49+,50+,51+,52-,53-,54-,55-,56-,57+,58-,59+,60-,61-,62-,63-/m1/s1
InChi Key:
ODLHGICHYURWBS-RYJYQAAZSA-N
MDL:
MFCD00074978
Molecular Formula:
C63H112O42
Molecular Weight:
1541.54
Package Type:
Vial
Purity:
>98% (HPLC)
SMILES:
O[C@@H]([C@@H]1O)[C@H]2C(O[C@@H]1O[C@@H]([C@H]3O)C(O[C@@H]([C@H]3O)O[C@H]4[C@@H]([C@@H]([C@H](OC4COCC(O)C)O[C@@H]([C@@H]5O)C(O[C@@H]([C@H]5O)O[C@@H]6C(C([C@@H](O[C@@H]6COCC(O)C)O[C@@H]7C(C([C@@H](O[C@@H]7COCC(O)C)O[C@@H]([C@H]8O)C(O[C@@H]([C@H]8O)O2)COCC(O)C)O)O)O)O)COCC(O)C)O)O)COCC(O)C)COCC(O)C
Solubility:
Soluble in water (100mg/ml) or DMSO (10mg/ml).
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at RT.

Documents

References

(1) M.E. Brewster, et al.; Pharm. Res. 8, 792 (1991) | (2) T.F. Meert, et al.; Eur. J. Anaesthesiol. 9, 399 (1992) | (3) A.E. Christian, et al.; J. Lipid Res. 38, 2264 (1997) | (4) J. Peeters, et al.; J. Pharm. Sci. 91, 1414 (2002) | (5) V.M. Rao, et al.; Int. J. Pharm. 319, 98 (2006) | (6) C.W. Yong, et al.; Pharm. Res. 25, 1092 (2008) | (7) B.D. Shewale, et al.; Indian J. Pharm. Sci. 70, 255 (2008) | (8) M.E. Brewster, et al.; Eur. J. Pharm. Sci. 34, 94 (2008) | (9) T. Loftsson, et al.; Acta. Ophthalmol. 90, 603 (2012) | (10) A.R. Katageri & M.A. Sheikh; Int. Res. J. Pharm. 3, 52 (2012) | (11) M. Yokoo, et al.; PLoS One 10, e0141946 (2015) | (12) A.R.S. Couto, et al.; Materials 11, 1971 (2018)