Chemodex

4-Methylumbelliferyl N-acetyl-beta-D-glucosaminide

Product Code:
 
CDX-M0580
Product Group:
 
Dyes, Stains, and Probes
Supplier:
 
Chemodex
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short term: +4°C. Long term: -20°C
Chemical Structure

Chemical Structure 

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CodeSizePrice
CDX-M0580-M500500 mg£151.00
Quantity:
CDX-M0580-G0011 g£220.00
Quantity:
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This product comes from: Switzerland.
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  • Further Information
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Further Information

Appearance:
White powder.
CAS:
37067-30-4
Description:
4-Methylumbelliferyl N-acetyl-beta-D-glucosaminide (4-MUF-NAG) is a non-fluorescent but fluorogenic substrate for N-acetyl-beta-D-glucosaminidase (NAGase) yielding a blue fluorescent solution. It is a fluorogenic MU substrate for detecting NAGase, chitinase, chitobiase and N-acetylhexosaminidase in cell extracts and purified enzyme preparations using a fluorescence microplate reader or fluorometer. Hydrolysis of 4-MUF-NAG releases the fluorescent product 4-MU. Spectral Data. lambdaEx/lambdaEm= 360/450 nm (cleaved product, pH-dependent).
EClass:
32160000
Form:
solid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C18H21NO8/c1-8-5-14(22)26-12-6-10(3-4-11(8)12)25-18-15(19-9(2)21)17(24)16(23)13(7-20)27-18/h3-6,13,15-18,20,23-24H,7H2,1-2H3,(H,19,21)/t13-,15-,16-,17-,18-/m1/s1
InChi Key:
QCTHLCFVVACBSA-JVNHZCFISA-N
MDL:
MFCD00065481
Molecular Formula:
C18H21NO8
Molecular Weight:
379.36
Package Type:
Vial
Purity:
>98% (NMR)
SMILES:
O[C@H]1[C@H](O)[C@@H](NC(C)=O)[C@H](OC2=CC=C(C(C)=CC(O3)=O)C3=C2)O[C@@H]1CO
Solubility:
Soluble in DMSO or DMF.
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Number:
41105331
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

Documents

References

(1) P. Chow & B. Weissmann; Carbohydr. Res. 96, 87 (1981) | (2) S. Linko-Lopponen & M. Makinen; Anal. Biochem. 148, 50 (1985) | (3) N.N. Dewji, et al.; Biochem J. 234, 157 (1986) | (4) M. O'Brien & R.R. Colwell; Appl. Environ. Microbiol. 53, 1718 (1987) | (5) P.W. Mueller, et al.; J. Anal. Toxicol. 13, 188 (1989) | (6) B. el Moudni, et al.; Exp. Parasitol. 83, 167 (1996) | (7) H. Li, et al.; Appl. Microbiol. Biotechnol. 60, 420 (2002) | (8) J.L. Guthrie, et al.; Can. J. Microbiol. 51, 491 (2005) | (9) S. Litzinger, et al.; J. Biol. Chem. 285, 35675 (2010) | (10) E. Liebminger, et al.; Test 286, 10793 (2011) | (11) O. Li, et al.; Gene Ther. 27, 226 (2020) | (12) S. Vutharadhi & S.K. Nadimpalli; Plant Physiol. Biochem. 197, 107663 (2023)