Chemodex

Propiconazole

Product Code:
 
CDX-P0413
Product Group:
 
Other Biochemicals
Supplier:
 
Chemodex
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short term: +20°C. Long term: +4°C
Chemical Structure

Chemical Structure 

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CDX-P0413-M250250 mg£93.00
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This product comes from: Switzerland.
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  • Further Information
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Further Information

Appearance:
Yellow to light brown semi-solid.
CAS:
60207-90-1
Description:
Propiconazole is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via the demethylation of C-14, leading to fungal cell membrane disruption. Formulations containing propiconazole have been used in the control of fungi in agriculture. It inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450. Propiconazole inhibits the growth of T. deformans and R. stolonifer, as well as A. niger, M. fructigena, S. nodorum, T. harzanium, R. solani, and S. rolfsii at concentrations ranging from 0.1 to 5 ppm. This compound can be used as analytical reference material. Propiconazole increases production of reactive oxygen species (ROS), the number of DNA mutations, and the incidence of tumor formation in mouse liver. Shown to activate PXR and disrupt hepatic metabolism in mice.
EClass:
32160000
Form:
solid
GHS:
GHS07, GHS08, GHS09
Handling Advice:
Protect from light and moisture.
Hazards:
H302-H317-H360FD-H410
InChi:
InChI=1S/C15H17Cl2N3O2/c1-2-3-12-7-21-15(22-12,8-20-10-18-9-19-20)13-5-4-11(16)6-14(13)17/h4-6,9-10,12H,2-3,7-8H2,1H3
InChi Key:
STJLVHWMYQXCPB-UHFFFAOYSA-N
MDL:
MFCD00055299
Molecular Formula:
C15H17Cl2N3O2
Molecular Weight:
342.22
Package Type:
Vial
PG:
III
Precautions:
P202-P273-P280-P301 + P312-P302 + P352-P308 + P313
Purity:
>95% (NMR)
Signal word:
Danger
SMILES:
ClC1=CC(Cl)=CC=C1C2(CN3N=CN=C3)OC(CCC)CO2
Solubility:
Soluble in DMSO (20mg/ml), DMF, ethanol or acentonitrile.
Source / Host:
Synthetic
Transportation:
Excepted Quantity
UN Nummer:
UN3082
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.

Documents

References

(1) H. Vanden Bossche, te al.; Pestic. Sci. 15, 188 (1984) | (2) M. Sancholle, et al.; Pest. Biochem. Phys. 21, 31 (1984) | (3) J.A. Zarn, et al.; Environ. Health Perspect. 111, 255 (2003) | (4) M. Calonne, et al.; Chemosphere 87, 376 (2012) | (5) C.S. Mazur, et al. Toxicol. Lett. 232, 37 (2015) | (6) N.O. Costa, et al.; Toxicology 335, 55 (2015) | (7) J. Valades, et al.; Environ. Sci. Pollut. Res. Int. 26, 27808 (2019) | (8) B. Attema, et al; Arch. Toxicol. (Epub ahead of print) (2024)