Chemodex

Pemafibrate

Product Code:
 
CDX-P0721
Product Group:
 
Other Biochemicals
Supplier:
 
Chemodex
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short term: +4°C. Long term: +4°C
Chemical Structure

Chemical Structure 

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CodeSizePrice
CDX-P0721-M01010 mg£133.00
Quantity:
CDX-P0721-M05050 mg£429.00
Quantity:
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This product comes from: Switzerland.
Typical lead time: 7-10 working days.
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  • Further Information
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Further Information

Appearance:
White to yellow solid.
CAS:
848259-27-8
Description:
Pemafibrate is a peroxisome proliferator-activated receptor alpha agonist (PPARalpha EC50 = 1nM for transcriptional activity). Pemafibrate is selective for PPARalpha over PPARdelta and PPARgamma (EC50 = 2300 and 1000nM, respectively). PPARalpha is a transcription factor that is essential for regulation of lipid homeostasis and glucose metabolism and has been implicated in inflammation. Pemafibrate was associated with the inhibition of inflammatory responses without affecting cell proliferation or angiogenesis, and subsequently may induce an anti-atherosclerotic effect.
EClass:
32160000
Form:
solid
GHS:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H302-H315-H319-H335
InChi:
InChI=1S/C28H30N2O6/c1-3-25(27(31)32)35-23-9-6-8-20(18-23)19-30(28-29-24-10-4-5-11-26(24)36-28)16-7-17-34-22-14-12-21(33-2)13-15-22/h4-6,8-15,18,25H,3,7,16-17,19H2,1-2H3,(H,31,32)/t25-/m1/s1
InChi Key:
ZHKNLJLMDFQVHJ-RUZDIDTESA-N
MDL:
MFCD30533427
Molecular Formula:
C28H30N2O6
Molecular Weight:
490.56
Package Type:
Vial
Precautions:
P261-P305+P351+P338
Purity:
>98% (NMR)
Signal word:
Warning
SMILES:
CC[C@H](C(O)=O)OC1=CC(CN(C2=NC3=C(C=CC=C3)O2)CCCOC4=CC=C(OC)C=C4)=CC=C1
Solubility:
Soluble in DMSO (20mg/ml). Insoluble in water.
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.

Documents

References

(1) K. Kitajima, et al.; Atheroscl. 203, 75 (2009) | (2) N. Hennuyer, et al.; Atheroscl. 249, 200 (2016) | (3) Y. Honda, et al.; Sci. Rep. 7, 42477 (2017) | (4) N. Ferri, et al.; Expert. Opin. Investig. Drugs 26, 593 (2017) | (5) J.C. Fruchart; Cardiovasc. Diabetol. 16, 124 (2017) | (6) Y. Yamamoto, et al.; Biochem. Biophys. Res. Commun. 499, 239 (2018) | (7) J.C. Fruchart & R.D. Santos; Curr. Opin. Lipidol. 30, 419 (2019) | (8) Y. Sasaki, et al.; Sci. Rep. 10, 7818 (2020)