Piperlongumine
Product Code:
CDX-P0921
CDX-P0921
Regulatory Status:
RUO
RUO
Shipping:
Ambient
Ambient
Storage:
Short term: +20°C. Long term: +4°C
Short term: +20°C. Long term: +4°C
No additional charges, what you see is what you pay! *
| Code | Size | Price |
|---|
| CDX-P0921-M250 | 250 mg | £336.00 |
Quantity:
| CDX-P0921-M500 | 500 mg | £499.00 |
Quantity:
Prices exclude any Taxes / VAT
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* Rare exceptions are clearly labelled (only 0.14% of items!).
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This product comes from: Switzerland.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
- Further Information
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Further Information
Appearance:
White to off-white powder.
CAS:
20069-09-4
Description:
Piperlongumine is a cell-permeable, orally bioavailable natural product isolated from the plant species, Piper longum L, which selectively induces cell death in cancer cells that express both wild-type and mutant p53 but not in primary normal cells and non-transformed immortalized cells. Piperlongumine enhances wild-type p53 and PUMA expression, and inhibits the expression of several pro-survival proteins, including BCL2, surviving, and XIAP, in various types of cancer cells, but not in normal cells. It induces ROS and apoptosis in several human cancer cells (EJ, MDA-MB-231, U2OS and MDA-MB-435), possibly through interaction with oxidative stress responders such as GSTP1 and CBR1. Additionally, it exhibits anti-tumour effects and inhibits the formation of blood vessels in xenograft-tumour mice and inhibits tumor growth and their associated metastases in a MMTV-PyVT breast cancer transgenic mouse model (2.4mg/kg, daily for two weeks, i.p.). Piperlongumine possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, anticancer, antiplatelet, anxiolytic, antidepressant and antidiabetic activities.
EClass:
32160000
Form:
solid
GHS:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H302
InChi:
InChI=1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6-15(18)19/h4,6-8,10-11H,5,9H2,1-3H3/b8-7+
InChi Key:
VABYUUZNAVQNPG-BQYQJAHWSA-N
MDL:
MFCD00075706
Molecular Formula:
C17H19NO5
Molecular Weight:
317.34
Package Type:
Vial
Precautions:
P264-P270-P301 + P312-P501
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
O=C1N(C(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)=O)CCC=C1
Solubility:
Soluble in DMSO or DMF (both 20mg/ml).
Source / Host:
Plant
Transportation:
Non-hazardous
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
Documents
References
(1) A. Chatterjee & C.P Dutta; Tetrahedron 23, 1769 (1967) | (2) C.Y. Duh, et al.; J. Nat. Prod. 53, 1575 (1990) | (3) D.P. Bezerra, et al.; Z. Naturforsch. C 60, 539 (2005) | (4) D.P. Bezerra, et al.; Toxicol. In Vitro 21, 1 (2007) | (5) M. Iwashita, et al.; Eur. J. Pharmacol. 570, 38 (2007) | (6) F.F. C?cero Bezerra, et al.; Phytomedicine 14, 605 (2007) | (7) H. Zhang, et al.; Bioorg. Med. Chem. Lett. 18, 3272 (2008) | (8) E.H. Kong, et al.; Oncol. Rep. 20, 785 (2008) | (9) J.B. Fontenele, et al.; J. Pharm. Pharmacol. 61, 511 (2009) | (10) L. Raj, et al.; Nature 475, 231 (2011) | (11) J. Moraes, et al.; Exp. Parasitol. 127, 357 (2011) | (12) K.V. Golovine, et al.; Prostate 73, 23 (2013) | (13) J. Zheng, et al.; Sci. Rep. 6, 26357 (2016) | (14) W. Harshbarger, et al.; J. Biol. Chem. 292, 112 (2017) | (15) E. Bosc, et al.; BBRC 496, 961 (2018) | (16) P. Xu, et al.; J. Biochem. Mol. Toxicol. 35, 1 (2021)