Sorafenib tosylate
Product Code:
CDX-S0264
CDX-S0264
Regulatory Status:
RUO
RUO
Shipping:
Ambient
Ambient
Storage:
Short term: +20°C. Long term: +4°C
Short term: +20°C. Long term: +4°C
No additional charges, what you see is what you pay! *
| Code | Size | Price |
|---|
| CDX-S0264-G005 | 5 g | £81.00 |
Quantity:
| CDX-S0264-G025 | 25 g | £290.00 |
Quantity:
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This product comes from: Switzerland.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
- Further Information
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Further Information
Appearance:
White to dark brown powder.
CAS:
475207-59-1
Description:
Sorafenib tysolate is a multi-kinase inhibitor that inhibits Raf-1 and B-RAF (IC50s = 6n and 22nM, respectively), as well as the receptor tyrosine kinases VEGFR2, VEGFR3, PDGFRbeta, Flt-3, c-Kit, FGFR-1 (Flt-2) and RET, involved in neovascularization and tumor progression. It is selective for these kinases over 12 other kinases, including ERK1, MEK1, EGFR, and HER2 (IC50s = >10uM for all). Sorafenib tosylate exerts broad-spectrum anticancer activity and disrupts signaling pathways that are vital for tumor growth and angiogenesis.
EClass:
32160000
Form:
solid
GHS:
GHS08, GHS09
Handling Advice:
Protect from light and moisture.
Hazards:
H360FD-H362-H372-H410
InChi:
InChI=1S/C21H16ClF3N4O3.C7H8O3S/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25;1-6-2-4-7(5-3-6)11(8,9)10/h2-11H,1H3,(H,26,30)(H2,28,29,31);2-5H,1H3,(H,8,9,10)
InChi Key:
IVDHYUQIDRJSTI-UHFFFAOYSA-N
MDL:
MFCD08235032
Molecular Formula:
C21H16ClF3N4O3 . C7H8SO3
Molecular Weight:
637.03
Package Type:
Vial
PG:
III
Precautions:
P202-P260-P263-P264-P273-P308 + P313
Purity:
>98% (HPLC)
Signal word:
Danger
SMILES:
ClC1=C(C(F)(F)F)C=C(NC(NC2=CC=C(OC3=CC(C(NC)=O)=NC=C3)C=C2)=O)C=C1.CC4=CC=C(S(=O)(O)=O)C=C4
Solubility:
Soluble in DMSO (5mg/ml).
Source / Host:
Synthetic
Transportation:
Excepted Quantity
UN Nummer:
UN3077
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
Documents
References
(1) J.F. Lyons, et al.; Endocr. Relat. Cancer 8, 219 (2001) | (2) S.M. Wilhelm, et al.; Cancer Res. 64, 7099 (2004) | (3) L. Liu, et al.; Cancer Res. 66, 11851 (2006) | (4) D.A. Murphy, et al.; Am. J. Pathol. 169, 1875 (2006) | (5) S. Wilhelm, et al.; Nat. Rev. Drug Discov. 5, 835 (2006) | (6) S.M. Wilhelm, et al.; Mol. Cancer Ther. 7, 3129 (2008) | (7) M.J. Gnoth, et al.; Drug Metab. Dispos. 38, 1341 (2010) | (8) M. Merz, et al.; Eur. J. Cancer. 47, 277 (2011) | (9) S.J. Dixon, et al.; Elife 3, e02523 (2014) | (10) J. Hasskarl; Recent Results Cancer Res. 201, 145 (2014) | (11) L. Wang, et al.; Polymers 15, 2638 (2023) | (12) M. Hendrixson, et al.; Med. Sci. 12, 20 (2024)