Chemodex

Sunitinib malate

Product Code:
 
CDX-S0330
Product Group:
 
Other Biochemicals
Supplier:
 
Chemodex
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short term: +20°C. Long term: +20°C
Chemical Structure

Chemical Structure 

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CDX-S0330-G0011 g£255.00
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This product comes from: Switzerland.
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Further Information

Appearance:
Yellow, orange to brown powder.
CAS:
341031-54-7
Description:
Sunitinib malate is a potent ATP-competitive and cell permeable multi-targeted receptor tyrosine kinase (RTK) inhibitor targeting VEGFR, PDGFR-beta and c-Kit (Ki = 2-17nM). It inhibits FLK1 (Ki=9nM), PDGFRbeta (Ki=8nM) and FLT3. It is at least 10-fold selective for FLK1 and PDGFRbeta over a variety of tyrosine kinases in a panel, including EGFR, Cdk2, Met, IGFR-1, Abl and Src. Sunitinib malate inhibits the cellular receptor phosphorylation of FLT3, RET and CSF-1R. Sunitinib malate exhibits potent antiangiogenic and antitumor activity in multiple xenograft models. It decreases VEGF- and FGF-induced proliferation of human umbilical vein endothelial cells (HUVECs) and reduces tumor growth in a variety of mouse xenograft models when administered at doses ranging from 20 to 80 mg/kg per day.
EClass:
32160000
Form:
solid
GHS:
GHS08
Handling Advice:
Protect from light and moisture.
Hazards:
H360-H372
InChi:
InChI=1S/C22H27FN4O2.C4H6O5/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28;5-2(4(8)9)1-3(6)7/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28);2,5H,1H2,(H,6,7)(H,8,9)/b17-12-;
InChi Key:
LBWFXVZLPYTWQI-IPOVEDGCSA-N
MDL:
MFCD08282795
Molecular Formula:
C22H27FN4O2 . C4H6O5
Molecular Weight:
532.56
Package Type:
Vial
Precautions:
P202-P260-P264-P280-P308 + P313-P405
Purity:
>98% (HPLC)
Signal word:
Danger
SMILES:
CC1=C(/C=C2C(NC3=C\2C=C(F)C=C3)=O)NC(C)=C1C(NCCN(CC)CC)=O.O[C@H](C(O)=O)CC(O)=O
Solubility:
Soluble in DMSO (10mg/ml).
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at RT.

Documents

References

(1) L. Sun, et al.; J. Med. Chem. 46, 1116 (2003) | (2) D. B. Mendel, et al.; Clin. Cancer Res. 9, 327 (2003) | (3) A.M. O'Farrell, et al.; Blood 101, 3597 (2003) | (4) J. Guo, et al.; Mol. Cancer. Ther. 5, 1007 (2006) | (5) E.D. Deeks & G.M. Keating; Drugs 66, 2255 (2006) | (6) S. Faivre, et al.; Nat. Rev. Drug Discov. 6, 734 (2007) | (7) R. Roskoski; BBRC 356, 323 (2007)