anti-LTbetaR (mouse) mAb (4H8 WH2)
Product Code:
AG-20B-0008
Antibody Clonality:
Monoclonal
Applications:- Flow Cytometry
- Functional Study
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This product comes from:
Switzerland.
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7-10 working days.
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Further Information
Alternate Names/Synonyms:
Lymphotoxin-beta Receptor; Tumor Necrosis Factor Receptor 2 Related Protein; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor Superfamily Member 3; TNFRSF3
1mg/ml
32160000
liquid
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Recombinant mouse LTbetaR (cysteine-rich region/aa 31-221).
Monoclonal Antibody. Recognizes mouse LTbetaR. Isotype: Rat IgG2a. Clone: 4H8 WH2. Applications: FACS, FUNC (Blocking). Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
P50284
The monoclonal antibody to mouse LTbetaR is an agonist that can be used for the investigation of the regulation of BAFF (BlyS), chemokines and integrins using in vivo and tissue culture models, the development of NK cells and NK T cells, to study the regulation of NF-kappaB family of transcription factors in regulation of inflammation and homeostasis, particularly RelB NF-kappaB2 pathway. For use as an agonist the MAb to LTbetaR is added to cell cultures at 2µg/ml. For in vivo use, mice are injected intraperitoneally with 50µg of agonistic MAb to LTbetaR in sterile phosphate saline buffer.
Plastic Vial
The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
>95% (SDS-PAGE)
Purified from concentrated hybridoma tissue culture supernatant.
Recognizes mouse LTbetaR.
Non-hazardous
Primary Antibodies
12352203
Stable for at least 1 year after receipt when stored at -20°C.