ProSci

DcR1 Antibody

Product Code:
 
PSI-2299
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Western Blot (WB)
1 / 3
Western blot analysis of DcR1 in HeLa cell (A), mouse (B) and rat (C) liver tissue lysates with DcR1 antibody at 1 μg/mL.
2 / 3
Immunofluorescence of DcR1 in rat liver tissue with DcR1 antibody at 10 μg/mL.
3 / 3
Immunofluorescence of DcR1 in Rat Liver cells with DcR1 antibody at 20 μg/mL.
❮❯

Western blot analysis of DcR1 in HeLa cell (A), mouse (B) and rat (C) liver tissue lysates with DcR1 antibody at 1 μg/mL.
Immunofluorescence of DcR1 in rat liver tissue with DcR1 antibody at 10 μg/mL.
Immunofluorescence of DcR1 in Rat Liver cells with DcR1 antibody at 20 μg/mL.

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CodeSizePrice
PSI-2299-0.02mg0.02mg£150.00
Quantity:
PSI-2299-0.1mg0.1mg£449.00
Quantity:
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Further Information

Additional Names:
DcR1 Antibody: LIT, DCR1, TRID, CD263, TRAILR3, TRAIL-R3, DCR1-TNFR, LIT, UNQ321/PRO366, Tumor necrosis factor receptor superfamily member 10C, Decoy TRAIL receptor without death domain, DcR1
Application Note:
DcR1 antibody can be used for detection of DcR1 by Western blot at 1 μg/mL. An approximate 65 kDa band can be detected. Antibody can also be used for immunoflourescence starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human, mouse, and rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Background:
DcR1 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts are expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.
Background References:
  • Pan G; O'Rourke K; Chinnaiyan et al.. The receptor for the cytotoxic ligand TRAIL. Science; 1997;276:111-113
  • Pan G, Ni J, Wei YF, et al. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 1997;277:815-8
  • Sheridan JP, Marsters SA, Pitti RM, et al. A. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 1997;277:818-21
  • Degli-Esposti MA, Smolak PJ, Walczak H, et al, Smith CA. Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family. J Exp Med 1997;186(7):1165-70
Buffer:
DcR1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
DcR1 antibody was raised against a peptide corresponding to amino acids in the extracellular domain of human DcR1 precursor.

The immunogen is located within amino acids 90 - 140 of DcR1.
NCBI Gene ID #:
8794
NCBI Official Name:
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
NCBI Official Symbol:
TNFRSF10C
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
65 kDa
Protein Accession #:
AF012536
Protein GI Number:
2338421
Purification:
DcR1 Antibody is DEAE purified.
Research Area:
Apoptosis
Swissprot #:
O14798
User NOte:
Optimal dilutions for each application to be determined by the researcher.