ProSci

TCCR Antibody

Product Code:
 
PSI-2481
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
1 / 3
Western blot analysis of TCCR expression in human spleen tissue lysates with TCCR antibody at 1 μg/ml.
2 / 3
Immunohistochemistry of TCCR in human spleen tissue with TCCR antibody at 10 μg/mL.
3 / 3
Immunofluorescence of TCCR in A549 cells with TCCR antibody at 20 μg/mL.
❮❯

Western blot analysis of TCCR expression in human spleen tissue lysates with TCCR antibody at 1 μg/ml.
Immunohistochemistry of TCCR in human spleen tissue with TCCR antibody at 10 μg/mL.
Immunofluorescence of TCCR in A549 cells with TCCR antibody at 20 μg/mL.

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CodeSizePrice
PSI-2481-0.02mg0.02mg£150.00
Quantity:
PSI-2481-0.1mg0.1mg£449.00
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Further Information

Additional Names:
TCCR Antibody: CRL1, TCCR, WSX1, IL27R, IL-27RA, zcytor1, CRL1, UNQ296/PRO336, Interleukin-27 receptor subunit alpha, Cytokine receptor WSX-1, IL-27 receptor subunit alpha
Application Note:
TCCR antibody can be used for detection of TCCR by Western blot at 1 μg/mL. An approximately 70 kDa band can be detected. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
TCCR Antibody: Upon antigen challenge, T-helper cells differentiate into two functional distinct subsets, Th1 and Th2. Th1 cells produce IL-2, IFN-gamma and lymphotoxin-beta that augment cell mediated immune response while Th2 cells secrete IL-4, IL-5, and IL-10 that enhance humoral immunity. The function of T-helper cells is regulated by cytokines. A novel cytokine receptor was recently identified and cloned. It is a new member in the type I cytokine receptor family and designated TCCR for T-cell cytokine receptor and WSX-1. TCCR deficient mice had impaired Th1 responses to protein antigen challenge, including decreased levels of IFN-gamma and Th1-dependent antibody IgG2a. TCCR is predominately expressed in thymus, spleen, lymph notes and peripheral blood leukocytes.
Background References:
  • Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, Grewal IS and de Sauvage FJ. Development of Th1-type immune responses requires the type I cytokine receptor TCCR Nature 2000;407(6806):916-920
  • Sprecher,C.A., Grant,F.J., Baumgartner,J.W., Presnell,S.R., Schrader,S.K., Yamagiwa,T., Whitmore,T.E., O'Hara,P.J. and Foster,D.F. Cloning and characterization of a novel class I cytokine receptor Biochem. Biophys. Res. Commun. 1998;246(1):82-90
Buffer:
TCCR Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (87%)
Immunogen:
TCCR antibody was raised against a synthetic peptide corresponding to amino acids near the amino terminus of human TCCR precursor.

The immunogen is located within the first 50 amino acids of TCCR.
NCBI Gene ID #:
9466
NCBI Official Name:
interleukin 27 receptor, alpha
NCBI Official Symbol:
IL27RA
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
70 kDa
Protein Accession #:
NP_004834
Protein GI Number:
4759328
Purification:
TCCR Antibody is affinity chromatography purified via peptide column.
Research Area:
Apoptosis
Swissprot #:
Q6UWB1
User NOte:
Optimal dilutions for each application to be determined by the researcher.