Further Information
SHP2 Antibody: CFC, NS1, SHP2, BPTP3, PTP2C, PTP-1D, SH-PTP2, SH-PTP3, SHPTP2, Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D
SHP2 antibody can be used for the detection of SHP2 by Western blot at 0.5 - 2 μg/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
SHP2 Antibody: Src homology-2 domain containing protein (SHP2) is a member of the protein tyrosine phosphatase (PTP) family, a protein family that contains signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. SHP2 contains two tandem Src homology-2 (SH2) domains, which function as phosphotyrosine binding domains either directly or through scaffolding intermediates such as the insulin-receptor substrate 1 (IRS-1). These SH2 domains mediate the interaction of SHP2 with its substrates, allowing SHP2 to dephosphorylate proteins that inhibit signaling kinases such as ERK1 and AKT. SHP2 is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Recent experiments have shown SHP2 plays a significant role in hepatoprotection and liver regeneration.
- Yu Z, Ahmad S, Schwartz JL, et al. Protein-tyrosine phosphatase SHP2 is positively linked to proteinase-activated receptor 2-mediated mitogenic pathway. J. Biol. Chem.1997; 272:7519-24.
- Ostman A, Hellberg C, and Bohmer FD. Protein-tyrosine phosphatases and cancer. Nat. Rev. Cancer 2006; 6:307-20.
- Bard-Chapeau EA, Yuan J, Droin N, et al. Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection. Mol/ Cell. Biol. 2006; 26:4664-74.
SHP2 Antibody is supplied in PBS containing 0.02% sodium azide.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Chicken: (100%)
SHP2 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human SHP2.
The immunogen is located within amino acids 510 - 560 of SHP2.
5781
protein tyrosine phosphatase, non-receptor type 11
PTPN11
Homo sapiens
Liquid
NP_002825
33356177
SHP2 Antibody is affinity chromatography purified via peptide column.
Signal Transduction
Q06124
Optimal dilutions for each application to be determined by the researcher.