ProSci

KappaB ras2 Antibody

Product Code:
 
PSI-2495
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
1 / 1
Western blot analysis of KappaB ras2 in RAW264.7 cell lysate with KappaB ras2 antibody at 1 μg/mL in the (A) absence and (B) presence of blocking peptide.
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Western blot analysis of KappaB ras2 in RAW264.7 cell lysate with KappaB ras2 antibody at 1 μg/mL in the (A) absence and (B) presence of blocking peptide.

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CodeSizePrice
PSI-2495-0.02mg0.02mg£150.00
Quantity:
PSI-2495-0.1mg0.1mg£449.00
Quantity:
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Further Information

Additional Names:
KappaB ras2 Antibody: KBRAS2, kappaB-Ras2, KBRAS2, NF-kappa-B inhibitor-interacting Ras-like protein 2, I-kappa-B-interacting Ras-like protein 2, Kappa B-Ras protein 2
Application Note:
KappaB ras2 antibody can be used for detection of KappaB ras1 by Western blot at 1 μg/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Background:
KappaB ras2 Antibody: KappaB ras-1 (κB-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with IκB (IκB), an inhibitor of the transcription factor NF-κB. IκB exists in two homologous forms, IκB-alpha and IκB-beta, although IκB-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive IκB-alpha-NF-κB complexes can shuttle in and out of the nucleus, IκB-beta-NF-κB complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the IκB-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of IκB-beta and regulating the rate of degradation of IκB-beta. This antibody is specific for kappaB-ras2 and has no cross-reactivity to kappaB-ras1.
Background References:
  • Fenwick C, Na SY, Voll RE, et al. A subclass of Ras proteins that regulate the degradation of IkappaB. Science 2000; 287:869-73.
  • Chen Y, Wu J and Ghosh G. KappaB-Ras binds to the unique insert within the ankyrin repeat domain if IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta x NF-kappaB complexes. J. Biol. Chem.2003; 278:23101-6.
Buffer:
KappaB ras2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/ml
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Chicken: (93%)
Immunogen:
KappaB ras2 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human KappaB ras2.

The immunogen is located within the last 50 amino acids of KappaB ras2.
NCBI Gene ID #:
28511
NCBI Official Name:
NFKB inhibitor interacting Ras-like 2
NCBI Official Symbol:
NKIRAS2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_060065
Protein GI Number:
19072794
Purification:
KappaB ras2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
Swissprot #:
Q9NYR9
User NOte:
Optimal dilutions for each application to be determined by the researcher.