ProSci

Plxdc2 Antibody

Product Code:
 
PSI-4419
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
1 / 3
Western blot analysis of Plxdc2 in human colon tissue lysate with Plxdc2 antibody at (A) 0.5 (B) 1 μg/mL.
2 / 3
Immunohistochemical staining of human brain tissue using Plxdc2 antibody at 2.5 μg/mL.
3 / 3
Immunofluorescence of Plxdc2 in Human Brain cells with Plxdc2 antibody at 50 μg/mL.
❮❯

Western blot analysis of Plxdc2 in human colon tissue lysate with Plxdc2 antibody at (A) 0.5 (B) 1 μg/mL.
Immunohistochemical staining of human brain tissue using Plxdc2 antibody at 2.5 μg/mL.
Immunofluorescence of Plxdc2 in Human Brain cells with Plxdc2 antibody at 50 μg/mL.

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CodeSizePrice
PSI-4419-0.02mg0.02mg£150.00
Quantity:
PSI-4419-0.1mg0.1mg£449.00
Quantity:
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Further Information

Additional Names:
Plxdc2 Antibody: TEM7R, TEM7R, UNQ2514/PRO6003, Plexin domain-containing protein 2, Tumor endothelial marker 7-related protein
Application Note:
Plxdc2 antibody can be used for detection of Plxdc2 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
Plxdc2 Antibody: Plxdc2, also known as Tumor endothelial marker 7-related (TEM7R) encodes a protein with 57% amino acid identity to TEM7, the most abundant tumor endothelial marker. Plxdc2 is strongly expressed in the endothelial cells of the tumor stroma, but not in the endothelial cells of normal colonic tissue. Plxdc2 is also expressed at high levels in vessels of some normal tissues, with highest expression in muscle and lung. Plxdc2 and TEM7 may be important for tumor angiogenesis in humans. Cortactin was identified as a protein capable of binding to the extracellular region of both TEM7 and Plxdc2, and may provide new opportunities for the delivery of therapeutic and imaging agents to the vessels of solid tumors.
Background References:
  • Carson-Weber EB, Watkins DN, Nanda A, et al. Cell surface tumor epithelial markers are conserved in mice and humans. Cancer Res.2001; 61:6649-55.
  • Nabda A and St. Croix Bl. Tumor endothelial markers: new targets for cancer therapy. Curr Opin Oncol.2004; 16:44-9.
  • St. Croix B, Rago C, Velculescu V, et al. Genes expressed in human tumor endothelium. Science2000; 289:1197-202.
  • Nanda A, Buckhaults P, Seaman S, et al. Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R. Cancer Res.2004; 64:8507-11.
Buffer:
Plxdc2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Plxdc2 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human Plxdc2.

The immunogen is located within the last 50 amino acids of Plxdc2.
NCBI Gene ID #:
84898
NCBI Official Name:
plexin domain containing 2
NCBI Official Symbol:
PLXDC2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
Q6UX71
Protein GI Number:
74749416
Purification:
Plxdc2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
Swissprot #:
Q6UX71
User NOte:
Optimal dilutions for each application to be determined by the researcher.