Further Information
RUNX1 Antibody: AML1, CBFA2, EVI-1, AMLCR1, PEBP2aB, AML1-EVI-1, AML1, Runt-related transcription factor 1, Acute myeloid leukemia 1 protein, CBF-alpha-2
RUNX1 antibody can be used for detection of RUNX1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
RUNX1 Antibody: RUNX1 is one of three mammalian RUNX genes that control multiple aspects of embryonic development and are responsible for the pathogenesis of many human diseases. RUNX1 plays major roles in the development of nociceptive sensory neurons in addition to hematopoietic stem cells (HSC) with the exception of the erythroid lineage. During development, Notch signals mediate RUNX1 induction with SCL/GATA/Ets factors, and Wnt signals potentially cooperate with RUNX1 to facilitate adult HSC expansion via cooperative induction of cyclin D, cdk4, and other cell cycle regulators. In turn, RUNX1 regulates cell cycle transitions dependent on functional/physical interactions with other proteins such as HDAC1 and -3, mSin3A, p300, SMAD proteins, and LEF/TCF.
- Lund AH and van Lohuizen M. RUNX: a trilogy of cancer genes. Cancer Cell2002; 1:213-5.
- Inoue K, Shiga T, and Ito Y. Runx transcription factors in neuronal development. Neur. Dev.2008; 3:20.
- North TE, Stacy T, Matheny CJ, et al. Runx1 is expressed in adult mouse hematopoietic stem cells and differentiating myeloid and lymphoid cells, but not in maturing erythroid cells. Stem Cells2004; 22:158-68.
- Lee TI, Jenner RG, Boyer LA. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell2006; 125:301-13.
RUNX1 Antibody is supplied in PBS containing 0.02% sodium azide.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
RUNX1 antibody was raised against a 16 amino acid synthetic peptide from near the center of human RUNX1.
The immunogen is located within amino acids 160 - 210 of RUNX1.
861
runt-related transcription factor 1
RUNX1
Homo sapiens
Liquid
AAI36381
223459612
RUNX1 Antibody is affinity chromatography purified via peptide column.
Stem Cell
Q01196
Optimal dilutions for each application to be determined by the researcher.