Antibody Clonality:
Polyclonal
Applications:- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
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Further Information
NALP5 Antibody: MATER, NALP5, PAN11, PYPAF8, CLR19.8, MATER, NACHT, LRR and PYD domains-containing protein 5, Mater protein homolog
NALP5 antibody can be used for detection of NALP5 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
NALP5 Antibody: NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP5, also known as MATER, is a maternal gene required for early embryonic development in mice. Increased NALP5 expression was observed in two neuronal injury models, and transient expression of recombinant NALP5 in neurons induced caspase-3 activation and apoptosis, suggesting that NALP5 also plays a role in caspase activation and apoptosis in injured neurons, and may thus represent a novel target for therapeutic treatment in neurodegenerative disorders.
- Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol.2003; 4:95-104.
- Tian X, Pascal G, and Monget P. Evolution and functional divergence of NLRP genes in mammalian reproductive system. BMC Evol. Biol.2009; 9:202.
- Tong ZB, Gold L, Pfeiffer KE, et al. Mater, a maternal effect gene required for early embryonic development in mice. Nat. Genet.2000; 26:267-8.
- Frederick Lo C, Ning X, Gonzales C, et al. Induced expression of death domain genes NALP1 and NALP5 following neuronal injury. Biochem. Biophys. Res. Commun.2008; 366:664-9.
NALP5 Antibody is supplied in PBS containing 0.02% sodium azide.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NALP5 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human NALP5.
The immunogen is located within the last 50 amino acids of NALP5.
126206
NLR family, pyrin domain containing 5
NLRP5
Homo sapiens
Liquid
NP_703148
158321897
NALP5 Antibody is affinity chromatography purified via peptide column.
Innate Immunity
P59047
Optimal dilutions for each application to be determined by the researcher.