Further Information
IL-9 Antibody : P40, HP40, IL-9, Interleukin-9, Cytokine P40
WB: 1-4 μg/mL; IHC: 5 μg/mL; IF: 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples; Immunofluorescence in human samples. All other applications and species not yet tested.
Interleukin 9 (IL-9) is a cytokine secreted by TH2 lymphocytes that acts as a regulator of a variety of hematopoietic cells, stimulates cell proliferation and prevents apoptosis (1,2). It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins (3). The IL-9 gene has been identified as a candidate gene for asthma (4). Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness (5).
- Renauld et al. Cytokine 1990; 2:9-12.
- Tete et al. J. Biol. Homeost. Agents 2012; 26:319-26.
- Knoops and Renauld. Growth Factors 2004; 22:207-15.
- Nicolaides et al. Proc. Natl. Acad. Sci. USA 1997; 94:13175-80.
IL-9 Antibody is supplied in PBS containing 0.02% sodium azide.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Anti-IL-9 antibody (7495) was raised against a peptide corresponding to 16 amino acids near the carboxy terminus of human IL-9.
The immunogen is located within the last 50 amino acids of IL-9.
Human IL-9 has one isoform (144aa, 16kD). Mouse IL-9 has one isoform (144aa, 16kD) and Rat IL-9 also has one isoform (144aa, 16kD). 7495 can detect human isoform, but cannot detect mouse and rat.
3578
interleukin 9
IL9
homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 16kD
Observed: 22 kD (Post-modification: 4 N-linked glycosylations)
NP_000581
10834980
IL-9 Antibody is affinity chromatography purified via peptide column.
Immunology
IL-9 antibody is human specific. IL-9 antibody is predicted to no cross-react with IL-7.
P15248
Optimal dilutions for each application to be determined by the researcher.
Recombinant Protein Test (Figure 2): Anti-IL-9 antibodies (7495) detected human IL-9 recombinant protein at different concentrations.