Further Information
IL-1F10 Antibody: IL-38, FKSG75, IL1HY2, IL-1HY2, IL1-theta, FIL1-theta, FIL1T, IL38, UNQ6119/PRO20041, Interleukin-1 family member 10, Family of interleukin 1-theta, IL-1F10
WB: 1 μg/mL; IHC: 5 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples. All other applications and species not yet tested.
The cytokine IL-1 is responsible for initiating a variety of activities through the activation of transcription factors, NF-kappa B and AP-1, thereby promoting host response to injury or infection (1). IL-1F10 (Interleukin-1 family member 10), also known as FIL1T, IL1HY2 or FKSG75, is highly expressed in the skin, spleen and proliferating B-cells of the tonsil (2). IL-1F10 binds soluble IL-1 receptor type 1, and is one of nine Interleukin 1 families clustered on chromosome 2, where it is thought to participate in the regulation of adapted and innate immune responses (3). IL-1F10 and IL-1RN polymorphisms may play an important role in the susceptibility to developing rheumatoid arthritis (4).
- Towne et al. J. Biol. Chem. 2004; 279:13677-88.
- Lin et al. J. Biol. Chem. 2001; 276: 20597-602.
- Bensen et al. J. Interferon Cytokine Res. 2001; 21:899-904.
- Cruz-Robles et al. Immunol. Invest. 2009; 38:231-9.
IL-1F10 antibody is supplied in PBS containing 0.02% sodium azide.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Predicted species reactivity based on immunogen sequence: Mouse (100%) and Rat (88%).
Anti-IL-1F10 antibody (7503) was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human IL-1F10.
The immunogen is located within the last 50 amino acids of IL-1F10.
Human IL-1F10 has 2 isoforms, including isoform 1 (152aa, 17kD) and isoform 2 (152aa, 17kD). Mouse IL-1F10 has one isoform (152aa, 17kD) and Rat IL-1F10 also has one isoform (152aa, 17kD). 7503 can detect human, mouse and rat.
84639
interleukin 1 family, member 10 (theta)
IL1F10
homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 17kD
Observed: 17 kD
NP_775184
27894307
IL-1F10 antibody is affinity chromatography purified via peptide column.
Immunology
IL-1F10 antibody is human, mouse and rat reactive. Two isoforms of IL-1F10 exist.
Q8WWZ1
Optimal dilutions for each application to be determined by the researcher.
Recombinant Protein Test (Figure 1): Anti- IL-1F10 antibodies (7503) detected human IL-1F10 recombinant protein at different concentrations.