ProSci

COMMD7 Antibody

Product Code:
 
PSI-7541
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
1 / 3
Western blot analysis of COMMD7 in mouse spleen tissue lysate with COMMD7 antibody at 1 μg/ml.
2 / 3
Immunohistochemistry of COMMD7 in human spleen tissue with COMMD7 antibody at 5 μg/mL.
3 / 3
Immunofluorescence of COMMD7 in human spleen tissue with COMMD7 antibody at 20 μg/mL.
❮❯

Western blot analysis of COMMD7 in mouse spleen tissue lysate with COMMD7 antibody at 1 μg/ml.
Immunohistochemistry of COMMD7 in human spleen tissue with COMMD7 antibody at 5 μg/mL.
Immunofluorescence of COMMD7 in human spleen tissue with COMMD7 antibody at 20 μg/mL.

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CodeSizePrice
PSI-7541-0.02mg0.02mg£150.00
Quantity:
PSI-7541-0.1mg0.1mg£449.00
Quantity:
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Further Information

Additional Names:
COMMD7 Antibody: C20orf92, dJ1085F17.3, C20orf92, COMM domain-containing protein 7
Application Note:
COMMD7 antibody can be used for detection of COMMD7 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
COMMD7 (COMM domain-containing protein 7) plays a role in the regulation NF-kappaB (1). It associates with the NF-kB complex and suppresses its transcriptional activity (2). COMMD7 contains 1 COMM domain and widely expressed with highest expression in lung (3). COMMD7 is a newly identified gene overexpressed in hepatocellular carcinoma (HCC) (4). COMMD7 is associated with tumor invasion and poor prognosis by NF-kappaB signaling pathway (4).
Background References:
  • Maine GN and Burstein E. COMMD proteins and the control of the NF kappa B pathway. Cell Cycle 2007; 6:672-6.
  • Burstein E, Hoberg JE, Wilkinson AS, et al. COMMD proteins, a novel family of structural and functional homologs of MURR1. J. Biol. Chem. 2005; 280:22222-32.
  • Narindrasorasak S, Kulkarni P, Deschamps P, et al. Characterization and copper binding properties of human COMMD1 (MURR1). Biochemistry 2007; 46:3116-28.
  • Zheng L, Liang P, Li J, et al. ShRNA-targeted COMMD7 suppresses hepatocellular carcinoma growth. PLoS One 2012; 7:e45412.
Buffer:
COMMD7 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (95%)
Immunogen:
COMMD7 antibody was raised against a 19 amino acid peptide near the center of human COMMD7.

The immunogen is located within amino acids 90 - 140 of COMMD7.
NCBI Gene ID #:
149951
NCBI Official Name:
COMM domain containing 7
NCBI Official Symbol:
COMMD7
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 22 kDa

Observed: 21 kDa
Protein Accession #:
NP_444269
Protein GI Number:
151101369
Purification:
COMMD7 antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
SPECIFICITY:
COMMD7 antibody is human, mouse and rat reactive. Multiple transcript variants encoding different isoforms have been found for COMMD7.
Swissprot #:
Q86VX2
User NOte:
Optimal dilutions for each application to be determined by the researcher.