Further Information
NRG1, ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, NDF, SMDF, MST131
NRG1 antibody can be used for detection of NRG1 by ELISA at 1:62500. NRG1 antibody can be used for detection of NRG1 by western blot at 0.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Neuregulin 1 (NRG1) interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues.Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells.
- Masuda, K., PLoS Med. 5 (5), E94 (2008).
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
batch dependent
Unconjugated
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NRG1.
3084
neuregulin 1
NRG1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
32 kDa
NP_039253
7669518
Antibody is purified by peptide affinity chromatography method.
Transcription ,Membrane ,Cancer ,Signal Transduction ,Primary ///Neuroscience ,
Q15491
Optimal dilutions for each application to be determined by the researcher.