Further Information
S6K, PS6K, S6K1, STK14A, p70-S6K, p70S6KA, p70-alpha, S6K-beta-1, p70(S6K)-alpha, KS6B1, P70-S6K, RPS6KB1, S6K
Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200
Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. Promotes protein synthesis by phosphorylating PDCD4 at 'Ser-67' and targeting it for degradation.
- Satoru Eguchi et al. (1999) J Biol Chem, Vol. 274: 36843-36851Papst PJ, et al. (1998) J Biol Chem. 273 (24): 15077-84. Ulrike Krause et al. (2002) Eur. J. Biochem. 269: 3751-3759 cLe, X. F, et al. (2003) Oncogene 22: 484?97
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
p70 S6 Kinase (Ab-389) antibody was raised against a peptide sequence around aa.387~391 (G-F-T-Y-V) derived from Human p70 S6 Kinase.
6198
ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPS6KB1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
70, 85 kDa
NP_003152.1
4506737
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Apoptosis,Cancer
This antibody detects endogenous level of total p70 S6 Kinase protein.
P23443