Further Information
C11orf32, Low-density lipoprotein receptor relative with 11 ligand-binding repeats, LDLR relative with 11 ligand-binding repeats, LR11, LRP9, SORLA, gp250, SorLA-1, C11orf32
Western Blot:1:500 - 1:2,000
IHC(P):1:500 - 1:2,000
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.
SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.
- Scherzer CR. Offe K. Gearing M. et al. Arch Neurol. 2004, Aug, 61(8):1200-5.
- Gabrielsson BG. Olofsson LE. Sjogren A. et al. Obes Res. 2005, Apr, 13(4):649-52.
- Shah S. Yu G. Mol Interv. 2006, Apr, 6(2):74-6, 58. Review.
Ascitic fluid containing 0.03% sodium azide.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Purified truncated recombinant SORL1-MBP expressed in E. Coli strain BL21 (DE3).
6653
sortilin-related receptor, L(DLR class) A repeats containing
SORL1
Homo sapiens
Q92673
296452912
Neuroscience
Q92673
Optimal dilutions for each application to be determined by the researcher.