Further Information
SF, MGF, SCF, FPH2, KL-1, Kitl, SHEP7, BCR1, D22S11, SF
Western Blot: 1:500~1:1000
Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol-1, 4, 5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
- Lu H. S., Clogston C. L., Wypych J., Parker V. P., Lee T. D., Swiderek K., Baltera R. F. Jr., Patel A. C., Chang D. C., Brankow D. W., Liu X. -D., Ogden S. G., Karkare S. B., Hu S. S., Zsebo K. M., Langley K. E. Arch. Biochem. Biophys. 298:150-158 (1992)
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
SCF antibody was raised against a peptide sequence around aa.265~269 (E-K-E-R-E) derived from Human SCF.
4254
KIT ligand
KITLG
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
25 - 38 kDa
NP_000890.1
4505175
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Stem Cell
This antibody detects endogenous level of total SCF protein.
P21583