Further Information
IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CDW44, CSPG8, HCELL, HUTCH-I, ECMR-III, Ly-24, Pgp-1, HERMES, AU023126, AW121933, AW146109, CD44
The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24). CD44 is expressed on hematopoietic and non-hematopoietic cells, bone marrow myeloid cells, memory T lymphocytes, periphery activated B cells, CD4+ T lymphocytes, and CD8+ T lymphocytes. The periphery B and T lymphocytes upregulate the expression of CD44. CD44 binds to hyaluronan molecules, acting as an adhesion molecule.The IM7 antibody inhibits collagen-induced arthritis in DBA/1 mice, prevents central nervous system inflammation associated with experimental autoimmune encephalomyelitis, but exacerbates the experimental autoimmune thyroiditis in CBA/J mice. The IM7 antibody also cross-reacts with dog, human, pig, horse, cat, and cow leukocytes.
- Trowbridge, I. S., Lesley, J., Schulte, R., Hyman, R., Trotter, J. (1982). Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues.Immunogenetics,15(3), 299-312.
- Lesley, J., Trowbridge, I. S. (1982). Genetic characterization of a polymorphic murine cell-surface glycoprotein.Immunogenetics,15(3), 313-320.
- Nedvetzki, S., Walmsley, M., Alpert, E., Williams, R. O., Feldmann, M., Naor, D. (1999). CD44 involvement in experimental collagen-induced arthritis (CIA).Journal of autoimmunity,13(1), 39-47.
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
batch dependent
FITC
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
960; 12505
CD44 molecule (Indian blood group)
CD44
Homo sapiens; Mus musculus
liquid
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Immunology,Stem Cell
The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24).
P16070; P15379
Optimal dilutions for each application to be determined by the researcher.