Further Information
CD62, GRMP, PSEL, CD62P, GMP140, LECAM3, PADGEM, Lnhr, CD62L, Ly-22, Lyam1, Ly-m22, Lyam-1, LECAM-1, AI528707, L-selectin, SELP
The Psel.KO2.3 monoclonal antibody specifically reacts with mouse CD62P (P-Selectin), a 140 kDA type I transmembrane glycoprotein also known as granule membrane protein 140 (GMP-140). Upon activation it is quickly transported to the plasma membrane from the alpha-granules of platelets and WEibel-Palade bodies of endothelial cells. It is essential to the functions of cell adhesion during inflammatory reactions and in the interaction of platelets with monocytes and neutrophils. The Psel.KO2.3 antibody does not block adhesion and binds to an epitope common to several species including mouse, human, and rat.
- Massaguer, A., Engel, P., PrezdelPulgar, S., Bosch, J., Pizcueta, P. (2000). Production and characterization of monoclonal antibodies against conserved epitopes of Pselectin (CD62P).Tissue antigens,56(2), 117-128.
- Kansas, G. S. (1996). Selectins and their ligands: current concepts and controversies.Blood,88(9), 3259-3287.
- Bullard, D. C., Kunkel, E. J., Kubo, H., Hicks, M. J., Lorenzo, I., Doyle, N. A., ... Beaudet, A. L. (1996). Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice.The Journal of experimental medicine,183(5), 2329-2336.
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
batch dependent
PE
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
6403; 20344
selectin P (granule membrane protein 140kDa, antigen CD62)
SELP
Homo sapiens; Mus musculus
liquid
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Immunology
The Psel.KO2.3 monoclonal antibody specifically reacts with mouse CD62P (P-Selectin), a 140 kDA type I transmembrane glycoprotein also known as granule membrane protein 140 (GMP-140).
P16109; P18337
Optimal dilutions for each application to be determined by the researcher.