ProSci

CD80 Antibody [16-10A1] (APC)

Product Code:
 
PSI-76-047
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Hamster
Antibody Isotype:
 
Armenian Hamster IgG
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
16-10A1
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Flow Cytometry
Storage:
 
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
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C57Bl/6 splenocytes were stained with APC 16-10A1 with relevant isotype control in Red.
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C57Bl/6 splenocytes were stained with APC 16-10A1 with relevant isotype control in Red.

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PSI-76-047-0.1mg0.1mg£505.00
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Further Information

Additional Names:
B71, Ly53, TSA1, Cd28l, Ly-53, MIC17, Cd80
Background:
The 16-10A1 antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.
Background References:
  • Razi-Wolf, Z., Freeman, G. J., Galvin, F., Benacerraf, B., Nadler, L., Reiser, H. (1992). Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells.Proceedings of the National Academy of Sciences,89(9), 4210-4214.
  • Hathcock, K. S., Laszlo, G., Pucillo, C., Linsley, P., Hodes, R. J. (1994). Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.The Journal of experimental medicine,180(2), 631-640.
  • Harlan, D. M., Hengartner, H., Huang, M. L., Kang, Y. H., Abe, R., Moreadith, R. W., ... Freeman, G. J. (1994). Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness.Proceedings of the National Academy of Sciences,91(8), 3137-3141.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
APC
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
12519
NCBI Official Name:
CD80 antigen
NCBI Official Symbol:
Cd80
NCBI Organism:
Mus musculus
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Innate Immunity,Immunology
SPECIFICITY:
The 16-10A1 antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR).
Swissprot #:
Q00609
User NOte:
Optimal dilutions for each application to be determined by the researcher.